Keith A Wafford: search on Z-Library

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1

Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptors

Peter B Wingrove, Patrick Safo, Lola Wheat, Sally A Thompson, Keith A Wafford, Paul J Whiting

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 214 KB

english, 2002

2

Treating insomnia: Current and investigational pharmacological approaches

Bjarke Ebert, Keith A. Wafford, Stephen Deacon

Journal:

Pharmacology & Therapeutics

Year:

2006

Language:

english

File:

PDF, 925 KB

english, 2006

3

Mechanism of action of general anaesthetics — new information from molecular pharmacology

Sally-Anne Thompson, Keith Wafford

Journal:

Current Opinion in Pharmacology

Year:

2001

Language:

english

File:

PDF, 71 KB

english, 2001

4

Activity of chlormethiazole at human recombinant GABAA and NMDA receptors

Marcello Usala, Sally Anne Thompson, Paul J Whiting, Keith A Wafford

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 178 KB

english, 2003

5

Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors

Martin Mortensen, Bjarke Ebert, Keith Wafford, Trevor G. Smart

Journal:

The Journal of Physiology

Year:

2010

Language:

english

File:

PDF, 853 KB

english, 2010

6

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression

Wood, Christian M., Wafford, Keith A., McCarthy, Andrew P., Hewes, Nicola, Shanks, Elaine, Lodge, David, Robinson, Emma SJ.

Journal:

Neuropharmacology

Year:

2018

Language:

english

File:

PDF, 7.50 MB

english, 2018

7

Pyrazolopyridinones as functionally selective GABAA ligands

Wesley P. Blackaby, John R. Atack, Frances Bromidge, Richard Lewis, Michael G.N. Russell, Alison Smith, Keith Wafford, Ruth M. McKernan, Leslie J. Street, José L. Castro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 131 KB

english, 2005

8

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster

Caroline M Priestley, Elizabeth M Williamson, Keith A Wafford, David B Sattelle

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

9

Pharmacology of GABAA receptors exhibiting different levels of spontaneous activity

Martin Mortensen, Keith A Wafford, Peter Wingrove, Bjarke Ebert

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 354 KB

english, 2003

10

The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone

John R. Atack, Andy Pike, George Marshall, Jo Stanley, Rachael Lincoln, Susan M. Cook, Richard T. Lewis, Wesley P. Blackaby, Simon C. Goodacre, Ruth M. McKernan, Gerard R. Dawson, Keith A. Wafford, Da

Journal:

Neuropharmacology

Year:

2006

Language:

english

File:

PDF, 419 KB

english, 2006

11

Preferential co-assembly of recombinant NMDA receptors composed of three different subunits

Wafford, Keith A., Bain, Corrinna J., Bourdelles, Beatrice Le, Whiting, Paul J., Kemp, John A.

Journal:

Year:

1993

File:

PDF, 274 KB

1993

12

N-(Indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the α1 subunit

Ian Collins, William B Davey, Michael Rowley, Kathleen Quirk, Frances A Bromidge, Ruth M McKernan, Sally-Anne Thompson, Keith A Wafford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 153 KB

english, 2000

13

Benzodiazepine receptor agonists and insomnia: Is subtype selectivity lost in translation?

Bjarke Ebert, Keith A. Wafford

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2006

Language:

english

File:

PDF, 620 KB

english, 2006

14

REM sleep’s unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice

Nollet, Mathieu, Hicks, Harriet, McCarthy, Andrew P., Wu, Huihai, Möller-Levet, Carla S., Laing, Emma E., Malki, Karim, Lawless, Nathan, Wafford, Keith A., Dijk, Derk-Jan, Winsky-Sommerer, Raphaelle

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.41 MB

2019

15

Allosteric modulators affect the efficacy of partial agonists for recombinant GABAA receptors

Gábor Maksay, Sally A Thompson, Keith A Wafford

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 178 KB

english, 2000

16

New directions in kinetic high information content assays

Peter B. Simpson, Keith A. Wafford

Journal:

Drug Discovery Today

Year:

2006

Language:

english

File:

PDF, 722 KB

english, 2006

17

Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Simon C. Goodacre, David J. Hallett, Robert W. Carling, José L. Castro, David S. Reynolds, Andrew Pike, Keith A. Wafford, Robert Newman, John R. Atack, Leslie J. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 189 KB

english, 2006

18

Tricyclic pyridones as functionally selective human GABAAα2/3 receptor-ion channel ligands

James Crawforth, John R. Atack, Susan M. Cook, Karl R. Gibson, Alan Nadin, Andrew P. Owens, Andrew Pike, Michael Rowley, Alison J. Smith, Bindi Sohal, Francine Sternfeld, Keith Wafford, Leslie J. Stre

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 196 KB

english, 2004

19

The proconvulsant effects of the GABAA α5 subtype-selective compound RY-080 may not be α5-mediated

John R. Atack, Peter J. Bayley, Stephen R. Fletcher, Ruth M. McKernan, Keith A. Wafford, Gerard R. Dawson

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 224 KB

english, 2006

20

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones

Dianne R. Peden, Caroline M. Petitjean, Murray B. Herd, Murat S. Durakoglugil, Thomas W. Rosahl, Keith Wafford, Gregg E. Homanics, Delia Belelli, Jean-Marc Fritschy, Jeremy J. Lambert

Journal:

The Journal of Physiology

Year:

2008

Language:

english

File:

PDF, 1.45 MB

english, 2008

21

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

Keith A Wafford

Journal:

Current Opinion in Pharmacology

Year:

2005

Language:

english

File:

PDF, 179 KB

english, 2005

22

REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants

McCarthy, Andrew, Wafford, Keith, Shanks, Elaine, Ligocki, Marcin, Edgar, Dale M., Dijk, Derk-Jan

Journal:

Neuropharmacology

Year:

2016

Language:

english

File:

PDF, 2.79 MB

english, 2016

23

Effects of ageing on cortical neural dynamics and local sleep homeostasis in mice

McKillop, Laura E, Fisher, Simon P, Cui, Nanyi, Peirson, Stuart N, Foster, Russell G, Wafford, Keith A., Vyazovskiy, Vladyslav V

Journal:

Journal of Neuroscience

Year:

2018

Language:

english

File:

PDF, 9.76 MB

english, 2018

24

Orexin A induced increases in rat locus coeruleus neuronal activity are attenuated by systemic administration of OX1R and OX2R antagonists

Holton, Christopher M., Gilmour, Gary, Wafford, Keith A.

Journal:

Medicine in Drug Discovery

Year:

2020

File:

PDF, 1.38 MB

2020

25

Novel N1-(Benzyl)cinnamamidine Derived NR2B Subtype-Selective NMDA Receptor Antagonists.

Neil R. Curtis, Helen J. Diggle, Janusz J. Kulagowski, Clare London, Sarah Grimwood, Peter H. Hutson, Fraser Murray, Pawel Richards, Alison Macaulay, Wafford Keith A. Wafford Keith A.

Journal:

Year:

2003

File:

PDF, 140 KB

2003

26

6,7-Dihydro-2-benzothiophen-4(5 H )-ones: A Novel Class of GABA-A α5 Receptor Inverse Agonists

Chambers, Mark S., Atack, John R., Bromidge, Frances A., Broughton, Howard B., Cook, Susan, Dawson, Gerard R., Hobbs, Sarah C., Maubach, Karen A., Reeve, Austin J., Seabrook, Guy R., Wafford, Keith, M

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 64 KB

english, 2002

27

The pharmacology of spontaneously open α1β3ε GABAA receptor–ionophores

Gábor Maksay, Sally A. Thompson, Keith A. Wafford

Journal:

Neuropharmacology

Year:

2003

Language:

english

File:

PDF, 206 KB

english, 2003

28

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Gilmour, Gary, Broad, Lisa M., Wafford, Keith A., Britton, Thomas, Colvin, Ellen M., Fivush, Adam, Gastambide, Francois, Getman, Brian, Heinz, Beverly A., McCarthy, Andrew P., Prieto, Lourdes, Shanks,

Journal:

Neuropharmacology

Year:

2013

Language:

english

File:

PDF, 1.86 MB

english, 2013

29

Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders

Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P.,

Journal:

Neuropharmacology

Year:

2017

Language:

english

File:

PDF, 1.27 MB

english, 2017

30

ChemInform Abstract: N-(Indol-3-ylglyoxylyl)piperidines: High Affinity Agonists of Human GABA-A Receptors Containing the α1 Subunit.

Ian Collins, William B. Davey, Michael Rowley, Kathleen Quirk, Frances A. Bromidge, Ruth M. McKernan, Sally-Anne Thompson, Keith A. Wafford

Journal:

Year:

2000

File:

PDF, 37 KB

2000

31

The role of GABAAβ2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole

James O. Groves, Martin R. Guscott, David J. Hallett, Thomas W. Rosahl, Andrew Pike, Amy Davies, Keith A. Wafford, David S. Reynolds

Journal:

European Journal of Neuroscience

Year:

2006

Language:

english

File:

PDF, 246 KB

english, 2006

32

Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour

Ciara McCabe, David Shaw, John R Atack, Leslie J Street, Keith A Wafford, Gerard R Dawson, David S Reynolds, Julian C Leslie

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 161 KB

english, 2004

33

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunction

Philip Jones, John R. Atack, Matthew P. Braun, Brian P. Cato, Mark S. Chambers, Desmond O’Connor, Susan M. Cook, Sarah C. Hobbs, Robert Maxey, Helen J. Szekeres, Nicola Szeto, Keith A. Wafford, Angus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

34

2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: Functionally selective GABAA α3-subtype agonists

Robert W. Carling, Michael G.N. Russell, Kevin W. Moore, Andrew Mitchinson, Alexander Guiblin, Alison Smith, Keith A. Wafford, George Marshall, John R. Atack, Leslie J. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

35

Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit

Wafford, Keith A., Burnett, Donald M., Leidenheimer, Nancy J., Burt, David R., Wang, Jia Bei, Kofuji, Paulo, Dunwiddie, Thomas V., Harris, R.Adron, Sikela, James M.

Journal:

Year:

1991

Language:

english

File:

PDF, 1009 KB

english, 1991

36

The Interaction of the General Anesthetic Etomidate with the γ -Aminobutyric Acid Type a Receptor is Influenced by a Single Amino Acid

Delia Belelli, Jeremy J. Lambert, John A. Peters, Keith Wafford and Paul J. Whiting

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.06 MB

english, 1997

37

The Modulatory Action of Loreclezole at the γ-Aminobutyric Acid Type a Receptor is Determined by a Single Amino Acid in the β2and β3Subunit

Peter B. Wingrove, Keith A. Wafford, Corrina Bain and Paul J. Whiting

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1008 KB

english, 1994

38

Modelling maintenance of wakefulness in rats: comparing potential non-invasive sleep-restriction methods and their effects on sleep and attentional performance

Mccarthy, Andrew, Loomis, Sally, Eastwood, Brian, Wafford, Keith A., Winsky-Sommerer, Raphaëlle, Gilmour, Gary

Journal:

Journal of Sleep Research

Year:

2016

Language:

english

File:

PDF, 748 KB

english, 2016

39

Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time

Wafford, Keith A., Ebert, Bjarke

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 799 KB

english, 2008

40

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists

Neil R Curtis, Helen J Diggle, Janusz J Kulagowski, Clare London, Sarah Grimwood, Peter H Hutson, Fraser Murray, Pawel Richards, Alison Macaulay, Keith A Wafford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003

41

N-Methyl-d-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors

Sarah Grimwood,, Keith A. Wafford, Alison Macaulay, Pete H. Hutson

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 138 KB

english, 2002

42

Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia

Phillips, Keith G., Bartsch, Ullrich, McCarthy, Andrew P., Edgar, Dale M., Tricklebank, Mark D., Wafford, Keith A., Jones, Matt W.

Journal:

Year:

2012

Language:

english

File:

PDF, 713 KB

english, 2012

43

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

Post, Anke, Smart, Trevor S, Krikke-Workel, Judith, Dawson, Gerard R, Harmer, Catherine J, Browning, Michael, Jackson, Kimberley, Kakar, Rishi, Mohs, Richard, Statnick, Michael, Wafford, Keith, McCart

Journal:

Neuropsychopharmacology

Year:

2015

Language:

english

File:

PDF, 930 KB

english, 2015

44

γ-Aminobutyric Acid Type A Receptor β2 Subunit Mediates the Hypothermic Effect of Etomidate in Mice

Cirone, Jennifer, Rosahl, Thomas W., Reynolds, David S., Newman, Richard J., OʼMeara, Gillian F., Hutson, Peter H., Wafford, Keith A.

Journal:

Year:

2004

Language:

english

File:

PDF, 538 KB

english, 2004

45

Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro

Johnson, Nicholas W., Özkan, Mazhar, Burgess, Adrian P., Prokic, Emma J., Wafford, Keith A., O'Neill, Michael J., Greenhill, Stuart D., Stanford, Ian M., Woodhall, Gavin L.

Journal:

Neuropharmacology

Year:

2017

Language:

english

File:

PDF, 5.97 MB

english, 2017

46

The expression of GABAAβ subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells

Murray B. Herd, Alison R. Haythornthwaite, Thomas W. Rosahl, Keith A. Wafford, Gregg E. Homanics, Jeremy J. Lambert, Delia Belelli

Journal:

The Journal of Physiology

Year:

2008

Language:

english

File:

PDF, 731 KB

english, 2008

47

A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies

Post, Anke, Smart, Trevor S, Krikke-Workel, Judith, Dawson, Gerard R, Harmer, Catherine J, Browning, Michael, Jackson, Kimberley, Kakar, Rishi, Mohs, Richard, Statnick, Michael, Wafford, Keith, McCart

Journal:

Neuropsychopharmacology

Year:

2016

Language:

english

File:

PDF, 43 KB

english, 2016

48

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels

Collins, Ian, Moyes, Christopher, Davey, William B., Rowley, Michael, Bromidge, Frances A., Quirk, Kathleen, Atack, John R., McKernan, Ruth M., Thompson, Sally-Ann, Wafford, Keith

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 169 KB

english, 2002

49

Gaboxadol — a new awakening in sleep

Keith A Wafford, Bjarke Ebert

Journal:

Current Opinion in Pharmacology

Year:

2006

Language:

english

File:

PDF, 187 KB

english, 2006

50

Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABAA receptors

Bjarke Ebert, Martin Mortensen, Sally A. Thompson, Jan Kehler, Keith A. Wafford, Povl Krogsgaard-Larsen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

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